Please be advised that no photography or video/sound recording of conference presentations is allowed to take place during the conference.
Friday May 1, 2009 |
8.00 |
Registration |
9.00 |
Plenary presentation
AMD: Pathogenesis, genetics, mechanisms and treatments
Dean Bok, University of California- Los Angeles, USA |
|
Session 1 – The macula in health and disease
Chair: Gregory Hageman, University of Iowa, USA |
10.00 |
O1 – Overview of the macula: What have we ignored and forgotten
Gregory Hageman, University of Iowa, USA |
10.25 |
O2 – Geographic atrophy: Recent advances
Alan Bird, University of London, UK |
10.50 |
O3 – Gene expression profiling of the macular RPE/Choroid
Lincoln V. Jonson, University of California- Santa Barbara, USA |
11.15 |
O4 – Bruchs membrane protein accumulation and degradation in age-related macular degeneration
Philip Luthert, University College London, UK |
12.00 |
Lunch break |
|
Session 2: AMD gene defects: Focus on biology/clinical manifestations
Chair: Rando Allikmets, Columbia University, USA |
13.00 |
O5 – Overview of AMD genetics May 2009
Rando Allikmets, Columbia University, USA |
13.25 |
O6 - CFH, C3 and ARMS2 are significant risk loci for age-related macular degeneration but not for late-stage disease progression
Bernhard Weber, University of Regensburg, Germany |
13.50 |
O7 – A binary causality model for the 10q26 AMD locus
Nico Katsanis, Johns Hopkins University School of Medicine, USA |
14.15 |
O8 – Structural thoughts on complement regulators and AMD
Susan M. Lea, University of Oxford, UK |
14.40 |
Refreshment break |
|
Session 3: Cone degeneration and cone survival
Chair: Connie Cepko, Harvard Medical School, USA
|
15.00 |
O9 – Photoreceptor Death in Retinitis Pigmentosa
Connie Cepko, Harvard Medical School, USA |
15.25 |
O10 - Cones Die From Oxidative and Nitrosative Damage in Retinitis Pigmentosa
Peter Campochiaro, Johns Hopkins Hospital School of Medicine, USA |
15.50 |
O11 - Understanding rod mediated cone death
Claudio Punzo, Harvard Medical School, USA |
16.15 |
O12 - Cone viability factors: Molecular and functional studies
José A Sahel, INSERM, France |
17.00 |
Poster session |
18.30 |
End of day 1 |
Saturday May 2, 2009 |
|
Session 4: Animal models of MD and cone dystrophies
Chair: Don Zack, Johns Hopkins University School of Medicine, USA |
8.00 |
O13 - Iron overload as a potential culprit in AMD
Joshua Dunaief, University of Pennsylvania, USA |
8.20 |
O14 - An animal model for AMD based on an inflammatory signal discovered in AMD donor eye tissue
Joe Hollyfield, The Cleveland Clinic Lerner College of Medicine, USA |
8.40 |
O15 - A smoke induced animal model of AMD
James T. Handa, Wilmer Eye Institute, USA |
9.00 |
O16 - Col4a1 mutant mice are a genetically complex model of AMD phenotypes
Doug Gould, University of California – San Francisco, USA |
9.20 |
NEW PRESENTATION- Microglial cells and AMD: Inflammatory chemokines receptor knockout models
Florian Sennlaub, INSERM, France
|
9.40 |
Refreshment break |
|
Session 5: Gene-based therapies in animal models of MD
Chair: Jean Bennett, University of Pennsylvania, USA |
10.00 |
O17 - Gene therapy for cone photoreceptor disease
William Hauswirth, University of Florida, USA |
10.25 |
O18 - AAV-mediated gene transfer for macular degeneration
Alberto Auricchio, Telethon Institute of Genetics and Medicine, Italy |
10.50 |
O19 - Inhibition of human complement mediated damage to murine RPE
Rajendra Kumar-Singh, Tufts University, USA |
11.15 |
O20 - Gene therapy for choroidal neovascularization
Abraham Scaria, Genzyme Corporation, USA |
11.40 |
Lunch break |
|
Session 6: AMD/Angiogenesis/VEGF
Chair: Balamurali Krishna Ambati, University of Utah, USA |
13.00 |
Introduction Session 6 - Selectively homing nanoparticles can deliver Flt23K intraceptor-expressing plasmids to inhibit CNV
Balamurali Krishna Ambati, University of Utah, USA |
13.10 |
O21 - An integrin antagonist for preventing neovascular AMD
Anthony P. Adamis, Jerini Ophthalmics, USA |
13.30 |
O22 – RTEF-1 Isoforms and regulation of VEGF
Binoy Appukuttan, Casey Eye Institute, USA |
13.50 |
O23 - Toll-like receptor-3 in geographic atrophy: Deciphering mechanisms and developing therapies
Jayakrishna Ambati, University of Kentucky, USA |
14.10 |
O24 – Death of choriocapillaris in wet and dry AMD
Gerard Lutty, Johns Hopkins Hospital, USA |
14.30 |
O25 – RORA, a potential therapeutic target for neovascular AMD
Margaret DeAngelis, Harvard Medical School, USA |
14.40 |
Refreshment break |
|
Session 7: Nutritional biochemistry of macular degeneration
Chair: Paul Bernstein, University of Utah, USA |
15.00 |
O26 - The protective role of carotenoids in the human eye: Insights from asian silkworms and transgenic mice
Paul Bernstein, University of Utah, USA |
15.25 |
O27 - Targeting lipofuscin in the treatment of AMD
Michael Boulton, University of Florida, USA |
15.50 |
O28 - ELOVL4 protein and very long chain polyunsaturated fatty acid biosynthesis
Robert E. Anderson, University of Oklahoma, USA |
16.15 |
O29 - Mechanisms and Therapies Directed Towards the Bisretinoid Pigments that Constitute RPE Lipofuscin
Janet Sparrow, Columbia University, USA |
17.00 |
Closing remarks |
